Variables Influencing the Depth of Conscious Sedation in Plastic Surgery: A Prospective Study

• Published in: Archives of plastic surgery 2017, 44(1), , pp.5-11
• Main Authors: Yeo, Hyeonjung, Kim, Wonwoo, Park, Hyochun, Kim, Hoonnam
• Format: Article
• Language: English
• Subjects: conscious sedation; consciousness monitors; deep sedation; hypnotics and sedatives; Original; Original Article; 성형외과학
• ISSN: 2234-6163; 2234-6171
• DOI: 10.5999/aps.2017.44.1.5

Background Conscious sedation has been widely utilized in plastic surgery. However, inadequate research has been published evaluating adequate drug dosage and depth of sedation. In clinical practice, sedation is often inadequate or accompanied by complications when sedatives are administered according to body weight alone. The purpose of this study was to identify variables influencing the depth of sedation during conscious sedation for plastic surgery. Methods This prospective study evaluated 97 patients who underwent plastic surgical procedures under conscious sedation. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and glucose levels were measured. Midazolam and ketamine were administered intravenously according to a preset protocol. Bispectral index (BIS) recordings were obtained to evaluate the depth of sedation 4, 10, 15, and 20 minutes after midazolam administration. Associations between variables and the BIS were assessed using multiple regression analysis. Results Alcohol intake and female sex were positively associated with the mean BIS (P