Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina

The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Sixty-three patients who underwent corona...

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Published in:Korean circulation journal 2017, 47(1), , pp.44-49
Main Authors: Efe, Tolga Han, Açar, Burak, Ertem, Ahmet Göktuğ, Yayla, Kadriye Gayretli, Algül, Engin, Yayla, Çağrı, Ünal, Sefa, Bilgin, Murat, Çimen, Tolga, Kirbaş, Özgür, Yeter, Ekrem
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container_title Korean circulation journal
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creator Efe, Tolga Han
Açar, Burak
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Bilgin, Murat
Çimen, Tolga
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Yeter, Ekrem
description The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (
doi_str_mv 10.4070/kcj.2016.0079
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The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (&lt;23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer's protocol. The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score &lt;23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p&lt;0.001). 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내과학
title Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina
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