SR Proteins: Binders, Regulators, and Connectors of RNA

Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program....

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Bibliographic Details
Published in:Molecules and cells 2017, 40(1), , pp.1-9
Main Author: Jeong, Sunjoo
Format: Article
Language:English
Subjects:
Arginine - genetics
Arginine - metabolism
Humans
Minireview
Protein Binding
Protein Biosynthesis
RNA - genetics
RNA - metabolism
RNA Splicing
Serine - genetics
Serine - metabolism
Serine-Arginine Splicing Factors - genetics
Serine-Arginine Splicing Factors - metabolism
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Summary:Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2017.2319