Thymoma and Synchronous Primary Mediastinal Seminomas with Florid Follicular Lymphoid Hyperplasia in the Anterior Mediastinum: A Case Report and Review of the Literature

Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular semino...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2017, 51(2), , pp.165-170
Main Authors: Lee, Hyang-Im, Jang, In-Seok, Jeon, Kyung Nyeo, Ko, Gyung Hyuck, Lee, Jong Sil, Kim, Dong Chul, Song, Dae Hyun, Lee, Jeong-Hee
Format: Article
Language:English
Subjects:
Cancer
Case reports
Case Study
Cysts
Follicular hyperplasia
Lymphocytes
Mediastinum
Metastasis
Seminoma
Smooth muscle
Thymoma
Tumors
Young adults
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Summary:Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously. The patient underwent a thymectomy for the removal of the mediastinal masses, one of which was diagnosed as type B2 invasive thymoma, and two of which were diagnosed as primary mediastinal seminomas with massive follicular hyperplasia. The patient received adjuvant chemotherapy after surgical resection. To our knowledge, this is the first description of a thymoma and a mediastinal seminoma occurring simultaneously in the thymus. We present this case along with a literature review.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2016.08.24