Effect of fermented soybean products intake on the overall immune safety and function in mice

Various functional activities have been reported for the fermented soybean products (DJ) and (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 we...

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Published in:Journal of veterinary science (Suwŏn-si, Korea) 2017, 18(1), , pp.25-32
Main Authors: Lee, Jae Hee, Paek, Se Hee, Shin, Hye Won, Lee, Seung Yeon, Moon, Byoung Seok, Park, Jung Eun, Lim, Gyeong Dong, Kim, Chang Yul, Heo, Yong
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Animals
Diet
Fermentation
Glycine max - metabolism
Immunity, Innate
Listeriosis - immunology
Listeriosis - microbiology
Listeriosis - veterinary
Male
Mice - immunology
Mice - metabolism
Mice, Inbred BALB C
Original
Rodent Diseases - immunology
Rodent Diseases - microbiology
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Summary:Various functional activities have been reported for the fermented soybean products (DJ) and (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer cell activity was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Th1)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-γ . IL-4 and IgG2a . IgG1 in stimulated splenic T and B cells, respectively. Resistance to infection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Th1 responses.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2017.18.1.25