Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis

OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. A systematic literature review was performed to identify all published randomi...

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Bibliographic Details
Published in:International neurourology journal 2017, 21(1), , pp.53-61
Main Authors: Yuan, Hejia, Cui, Yuanshan, Wu, Jitao, Peng, Peng, Sun, Xujie, Gao, Zhenli
Format: Article
Language:English
Subjects:
Meta-Analysis
Neurogenic Detrusor Overactivity
OnabotulinumtoxinA
Original
Randomized Controlled Trial
비뇨기과학
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Summary:OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment. A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogenic detrusor overactivity treatment. MEDLINE, Embase, and the CENTRAL were employed. Reference lists of retrieved studies were reviewed carefully. Six publications involving 871 patients, which compared onabotulinumtoxinA with a placebo were analyzed. Efficacy of onabotulinumtoxinA treatment was shown as a reduction of the mean number of urinary incontinence episodes per day (mean difference, -1.41; 95% confidence interval [CI], -1.70 to -1.12; P
ISSN:2093-4777
2093-6931
2093-6931
DOI:10.5213/inj.1732646.323