Syndrome of inappropriate antidiuretic hormone secretion associated with seronegative neuromyelitis optica spectrum disorder

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum...

Full description

Saved in:
Bibliographic Details
Published in:Kidney research and clinical practice 2017, 36(1), , pp.100-104
Main Authors: Oh, Shin Ju, Ihm, Chun Gyoo, Lee, Tae Won, Kim, Jin Sug, Kim, Da Rae, Park, Eun Ji, Jung, Su Woong, Lee, Ji-Hoon, Heo, Sung Hyuk, Jeong, Kyung Hwan
Format: Article
Language:English
Subjects:
Aquaporin-4
Case Report
Neuromyelitis optica
Syndrome of inappropriate antidiuretic hormone secretion
내과학
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum disorders are rare. NMO is a demyelinating disorder characterized by optic neuritis and transverse myelitis. Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel. However, some NMO patients show seronegative AQP4 antibody results. The spectrum of NMO has been changed, and new findings about the disease have been reported. Here, we report a case of seronegative NMO spectrum disorder associated with SIADH.
ISSN:2211-9132
2211-9140
DOI:10.23876/j.krcp.2017.36.1.100