Immunomodulatory effects of ethanol extract of germinated ice plant (Mesembryanthemum crystallinum)

The purpose of this study was to investigate the immunomodulatory activity of ice plant ( ) extract (IPE) and . Raji (a human B cell line) and Jurkat (a human T cell line) cells were treated with various doses of IPE and cell proliferation was measured by WST assay. Results showed that IPE promoted...

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Bibliographic Details
Published in:Laboratory animal research 2017, 33(1), , pp.32-39
Main Authors: Choi, Joo-Hee, Jo, Sung-Gang, Jung, Seoung-Ki, Park, Woo-Tae, Kim, Keun-Young, Park, Yong-Wook, Park, Jong-Hwan
Format: Article
Language:English
Subjects:
cell proliferation
cytokines
Ice plant extract (IPE)
lymphocyte
macrophage
Original
수의학
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Summary:The purpose of this study was to investigate the immunomodulatory activity of ice plant ( ) extract (IPE) and . Raji (a human B cell line) and Jurkat (a human T cell line) cells were treated with various doses of IPE and cell proliferation was measured by WST assay. Results showed that IPE promoted the proliferation of both Raji and Jurkat cells in a dose-dependent manner. IPE also enhanced IL-6 and TNF-α production in macrophages in the presence of lipopolysaccharide (LPS), although IPE alone did not induce cytokine production. Moreover, IPE treatment upregulated iNOS gene expression in macrophages in a time- and dose-dependent manner and led to the production of nitric oxide in macrophages in the presence of IFNγ. studies revealed that oral administration of IPE for 2 weeks increased the differentiation of CD4+, CD8+, and CD19+ cells in splenocytes. These findings suggested that IPE has immunomodulatory effects and could be developed as an immunomodulatory supplement.
ISSN:1738-6055
2233-7660
DOI:10.5625/lar.2017.33.1.32