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Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients
The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to mutation status (mutation, variant of uncertain significance [VUS], or wild type). We analyzed 116 patients whose genetic test results were available for mutation type and clin...
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Published in: | Cancer research and treatment 2017, 49(2), , pp.408-415 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to
mutation status (mutation, variant of uncertain significance [VUS], or wild type).
We analyzed 116 patients whose
genetic test results were available for mutation type and clinical features, including progression-free survival (PFS), overall survival (OS), and response rate. These characteristics were compared according to
mutation status.
Thirty-seven (37/116, 31.9%)
mutations were identified (
, 30;
, 7). Mutation of c.3627_3628insA (p.Leu1209_Glu1210?fs) in
was observed in five patients (5/37, 13.5%). Twenty-five patients had
VUSs (25/116, 21.6%). Personal histories of breast cancer were observed in 48.6% of patients with
mutation (18/37), 16.0% of patients with
VUS (4/25), and 7.4% of patients with
wild type (4/54) (p < 0.001). Patients with
mutation showed longer OS than those with
wild type (p=0.005). No significant differences were detected in PFS, OS, or response rates between patients with
VUS and
mutation (p=0.772, p=0.459, and p=0.898, respectively).
Patientswith
mutation had longer OS than thosewith
wild type. Patients with
mutation and
VUS displayed similar prognoses. |
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ISSN: | 1598-2998 2005-9256 |
DOI: | 10.4143/crt.2016.135 |