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Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients

The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to mutation status (mutation, variant of uncertain significance [VUS], or wild type). We analyzed 116 patients whose genetic test results were available for mutation type and clin...

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Published in:Cancer research and treatment 2017, 49(2), , pp.408-415
Main Authors: Eoh, Kyung Jin, Park, Hyung Seok, Park, Ji Soo, Lee, Seung-Tae, Han, Jeongwoo, Lee, Jung-Yun, Kim, Sang Wun, Kim, Sunghoon, Kim, Young Tae, Nam, Eun Ji
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Language:English
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Summary:The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to mutation status (mutation, variant of uncertain significance [VUS], or wild type). We analyzed 116 patients whose genetic test results were available for mutation type and clinical features, including progression-free survival (PFS), overall survival (OS), and response rate. These characteristics were compared according to mutation status. Thirty-seven (37/116, 31.9%) mutations were identified ( , 30; , 7). Mutation of c.3627_3628insA (p.Leu1209_Glu1210?fs) in was observed in five patients (5/37, 13.5%). Twenty-five patients had VUSs (25/116, 21.6%). Personal histories of breast cancer were observed in 48.6% of patients with mutation (18/37), 16.0% of patients with VUS (4/25), and 7.4% of patients with wild type (4/54) (p < 0.001). Patients with mutation showed longer OS than those with wild type (p=0.005). No significant differences were detected in PFS, OS, or response rates between patients with VUS and mutation (p=0.772, p=0.459, and p=0.898, respectively). Patientswith mutation had longer OS than thosewith wild type. Patients with mutation and VUS displayed similar prognoses.
ISSN:1598-2998
2005-9256
DOI:10.4143/crt.2016.135