The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet

The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Sixty rats were divided into five groups in descending order of body weight. Except for the control group,...

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Bibliographic Details
Published in:Journal of ginseng research 2017, 41(2), , pp.120-126
Main Authors: Kim, Min Hee, Lee, Jongsung, Jung, Sehyun, Kim, Joo Wan, Shin, Jae-Ho, Lee, Hae-Jeung
Format: Article
Language:English
Subjects:
blood coagulation
blood flow
ginseng berry
high-fat diet
lipid metabolite
기타의약학
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Summary:The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Sixty rats were divided into five groups in descending order of body weight. Except for the control group, the other four groups were fed a HFD containing 45% kcal from fat for 11 wk without GBx. GBx groups were then additionally treated by gastric gavage with GBx dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, or 150 (GBx 150) mg/kg body weight for 6 wk along with the HFD. To investigate the effects of GBx on rats fed a HFD, biochemical metabolite, blood coagulation assay, and histological analysis were performed. In the experiments to measure the serum levels of leptin and apolipoprotein B/A, GBx treatment attenuated the HFD-induced increases in these metabolites (p 
ISSN:1226-8453
2093-4947
DOI:10.1016/j.jgr.2016.01.004