Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives

Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practic...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2017, 51(3), , pp.224-241
Main Authors: Jeon, Yoon Kyung, Yoon, Sun Och, Paik, Jin Ho, Kim, Young A, Shin, Bong Kyung, Kim, Hyun-Jung, Cha, Hee Jeong, Kim, Ji Eun, Huh, Jooryung, Ko, Young-Hyeh
Format: Article
Language:English
Subjects:
Biopsy
Cell growth
Clonality test
Disease
Gene expression
Gene translocation
in situ hybridization, fluorescence
Kinases
Leukemia
Lymphocytes
Lymphoma
Lymphoproliferative disorders
Malignant lymphoma
Molecular diagnostics
Morphology
Mutation
Next-generation sequencing
Pathology
Pathology, molecular
Patients
Review
T cell receptors
Tumors
병리학
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Summary:Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2017.04.09