High Maternal Blood Mercury Level Is Associated with Low Verbal IQ in Children

The objective of the present study was to investigate the relationship of IQ in children with maternal blood mercury concentration during late pregnancy. The present study is a component of the Mothers and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Kor...

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Bibliographic Details
Published in:Journal of Korean medical science 2017, 32(7), 229, pp.1097-1104
Main Authors: Jeong, Kyoung Sook, Park, Hyewon, Ha, Eunhee, Shin, Jiyoung, Hong, Yun Chul, Ha, Mina, Park, Hyesook, Kim, Bung Nyun, Lee, Boeun, Lee, Soo Jeong, Lee, Kyung Yeon, Kim, Ja Hyeong, Kim, Yangho
Format: Article
Language:English
Subjects:
Child Development - drug effects
Child, Preschool
Cohort Studies
Diet - adverse effects
Female
Humans
Intelligence - drug effects
Intelligence - physiology
Intelligence Tests
Male
Mercury - adverse effects
Mercury - blood
Original
Pregnancy
Seafood - adverse effects
의학일반
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Summary:The objective of the present study was to investigate the relationship of IQ in children with maternal blood mercury concentration during late pregnancy. The present study is a component of the Mothers and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 553 children whose mothers underwent testing for blood mercury during late pregnancy. The children were given the Korean language version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R) at 60 months of age. Multivariate linear regression analysis, with adjustment for covariates, was used to assess the relationship between verbal, performance, and total IQ in children and blood mercury concentration of mothers during late pregnancy. The results of multivariate linear regression analysis indicated that a doubling of blood mercury was associated with the decrease in verbal and total IQ by 2.482 (95% confidence interval [CI], 0.749-4.214) and 2.402 (95% CI, 0.526-4.279), respectively, after adjustment. This inverse association remained after further adjustment for blood lead concentration. Fish intake is an effect modifier of child IQ. In conclusion, high maternal blood mercury level is associated with low verbal IQ in children.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2017.32.7.1097