Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO

The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized. This study aimed to investigate the prevalence of AR and its associated risk factors in preschool-aged children and to assess the clinical utility of fractional exhaled nitric oxide (FeNO). This gener...

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Published in:Allergy, asthma & immunology research 2017, Asthma & Immunology Research, 9(4), , pp.314-321
Main Authors: Yoon, Jisun, Choi, Yean Jung, Lee, Eun, Cho, Hyun Ju, Yang, Song I, Kim, Young Ho, Jung, Young Ho, Seo, Ju Hee, Kwon, Ji Won, Kim, Hyo Bin, Lee, So Yeon, Kim, Bong Seong, Shim, Jung Yeon, Kim, Eun Jin, Lee, Joo Shil, Hong, Soo Jong
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Language:English
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Summary:The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized. This study aimed to investigate the prevalence of AR and its associated risk factors in preschool-aged children and to assess the clinical utility of fractional exhaled nitric oxide (FeNO). This general population-based, cross-sectional survey included 933 preschool-aged (3- to 7-year-old) children from Korea. Current AR was defined as having nasal symptoms within the last 12 months and physician-diagnosed AR. The prevalence of current AR in preschool children was 17.0% (156/919). Mold exposure (adjusted odds ratio [aOR], 1.67; 95% confidence interval [CI], 1.15-2.43) and the use of antibiotics (aOR, 1.97; 95% CI, 1.33-2.90) during infancy were associated with an increased risk of current AR, whereas having an older sibling (aOR, 0.52; 95% CI, 0.35-0.75) reduced the risk. Children with current atopic AR had significantly higher geometric mean levels of FeNO compared to those with non-atopic rhinitis (12.43; range of 1standard deviation [SD], 7.31-21.14 vs 8.25; range of 1SD, 5.62-12.10, P=0.001) or non-atopic healthy children (8.58; range of 1SD, 5.51-13.38, P
ISSN:2092-7355
2092-7363
DOI:10.4168/aair.2017.9.4.314