Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study

• Published in: Journal of Korean medical science 2017, 32(8), 230, pp.1268-1274
• Main Authors: Oh, Dong Hyun, Ahn, Jin Young, Kim, Sang Il, Kim, Min Ja, Woo, Jun Hee, Kim, Woo Joo, Baek, Ji Hyeon, Kim, Shin Woo, Choi, Bo Youl, Lee, Mi Hwa, Choi, Ju Yeon, Han, Myung Guk, Kang, Chun, Kim, June Myung, Choi, Jun Yong
• Format: Article
• Language: English
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - diagnosis; Adult; Aged; Aged, 80 and over; Anti-Retroviral Agents - therapeutic use; Blood Glucose - analysis; Body Mass Index; Cohort Studies; Dyslipidemias - diagnosis; Dyslipidemias - etiology; HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - drug therapy; Hospitals; Humans; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Middle Aged; Original; Prevalence; Protease Inhibitors - therapeutic use; Republic of Korea - epidemiology; Risk Factors; Young Adult; 의학일반
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2017.32.8.1268

Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m², and 16.4% of the patients had a BMI over 25 kg/m². A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.