Mean platelet volume and vitamin D level

Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was mea...

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Published in:Annals of laboratory medicine 2014, 34(2), , pp.98-103
Main Authors: Cumhur Cure, Medine, Cure, Erkan, Yuce, Suleyman, Yazici, Tarkan, Karakoyun, Inanc, Efe, Hasan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Glucose - analysis
Blood Platelets - cytology
Cell Size
Female
Humans
Immunoassay
Luminescent Measurements
Male
Middle Aged
Original
Vitamin D - analysis
Vitamin D Deficiency - metabolism
Vitamin D Deficiency - pathology
Young Adult
병리학
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cited_by cdi_FETCH-LOGICAL-c429t-5e0202c1ade8bc52da1e5728a2c27ea787874fb53670e048aea1c9c7efddeaa63
cites cdi_FETCH-LOGICAL-c429t-5e0202c1ade8bc52da1e5728a2c27ea787874fb53670e048aea1c9c7efddeaa63
container_end_page 103
container_issue 2
container_start_page 98
container_title Annals of laboratory medicine
container_volume 34
creator Cumhur Cure, Medine
Cure, Erkan
Yuce, Suleyman
Yazici, Tarkan
Karakoyun, Inanc
Efe, Hasan
description Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of 20 ng/mL, respectively. The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P
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We investigated whether vitamin D deficiency is associated with high MPV. This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of &lt;10 ng/mL, 10-20 ng/mL, and &gt;20 ng/mL, respectively. The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P&lt;0.001) and Group 3 (25.6±6.3 ng/mL, P&lt;0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P&lt;0.001) and Group 2 (7.9±1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P=0.019) was independently associated with increased MPV. 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We investigated whether vitamin D deficiency is associated with high MPV. This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of &lt;10 ng/mL, 10-20 ng/mL, and &gt;20 ng/mL, respectively. The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P&lt;0.001) and Group 3 (25.6±6.3 ng/mL, P&lt;0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P&lt;0.001) and Group 2 (7.9±1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P=0.019) was independently associated with increased MPV. 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Linear regression analysis showed that low levels of vitamin D (β=-0.109, P=0.019) was independently associated with increased MPV. There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.</abstract><cop>Korea (South)</cop><pub>The Korean Society for Laboratory Medicine</pub><pmid>24624344</pmid><doi>10.3343/alm.2014.34.2.98</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Glucose - analysis
Blood Platelets - cytology
Cell Size
Female
Humans
Immunoassay
Luminescent Measurements
Male
Middle Aged
Original
Vitamin D - analysis
Vitamin D Deficiency - metabolism
Vitamin D Deficiency - pathology
Young Adult
병리학
title Mean platelet volume and vitamin D level
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