Correlations between Janus kinase 2 V617F allele burdens and clinicohematologic parameters in myeloproliferative neoplasms

This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). Clinical and hematologic features were reviewed for 103 MPN patients, including patients with...

Full description

Saved in:
Bibliographic Details
Published in:Annals of laboratory medicine 2012, 32(6), , pp.385-391
Main Authors: Ha, Jung-Sook, Kim, Yu-Kyung, Jung, Soon-Il, Jung, He-Ra, Chung, In-Sung
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Alleles
Female
Hematocrit
Hemoglobins - metabolism
Humans
Janus Kinase 2 - genetics
Leukocyte Count
Male
Middle Aged
Myeloproliferative Disorders - genetics
Myeloproliferative Disorders - pathology
Original
Polycythemia Vera - genetics
Polymorphism, Single Nucleotide
Primary Myelofibrosis - genetics
Thrombocythemia, Essential - genetics
병리학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). Clinical and hematologic features were reviewed for 103 MPN patients, including patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64 patients), and primary myelofibrosis (PMF, 17 patients). JAK2 V617F allele status and allele burdens were measured by allele-specific PCR and pyrosequencing, respectively. The JAK2 V617F mutation was detected in 95.5%, 68.8%, and 52.9% of PV, ET, and PMF patients, respectively. JAK2 V617F-positive ET patients were significantly older and exhibited higher neutrophil fractions, a higher frequency of thrombotic events, and a higher myelofibrosis rate than JAK2 V617F-negative patients (P
ISSN:2234-3806
2234-3814
DOI:10.3343/alm.2012.32.6.385