Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis

The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with...

Full description

Saved in:
Bibliographic Details
Published in:Annals of laboratory medicine 2012, 32(2), , pp.113-118
Main Authors: Duygu, Fazilet, Karsen, Hasan, Aksoy, Nurten, Taskin, Abdullah
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alanine Transaminase - blood
Antioxidants - metabolism
Carrier State
Catalase - blood
DNA, Viral - analysis
Female
Fibrosis
Hepatitis B - metabolism
Hepatitis B - pathology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - metabolism
Hepatitis B, Chronic - pathology
Humans
Lipid Peroxidation
Male
Middle Aged
Original
Oxidative Stress
Sulfhydryl Compounds - blood
Young Adult
병리학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels. ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P
ISSN:2234-3806
2234-3814
DOI:10.3343/alm.2012.32.2.113