Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis

The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with...

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Published in:Annals of laboratory medicine 2012, 32(2), , pp.113-118
Main Authors: Duygu, Fazilet, Karsen, Hasan, Aksoy, Nurten, Taskin, Abdullah
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alanine Transaminase - blood
Antioxidants - metabolism
Carrier State
Catalase - blood
DNA, Viral - analysis
Female
Fibrosis
Hepatitis B - metabolism
Hepatitis B - pathology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - metabolism
Hepatitis B, Chronic - pathology
Humans
Lipid Peroxidation
Male
Middle Aged
Original
Oxidative Stress
Sulfhydryl Compounds - blood
Young Adult
병리학
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creator Duygu, Fazilet
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description The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels. ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P
doi_str_mv 10.3343/alm.2012.32.2.113
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Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels. ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P&lt;0.001). Catalase levels increased in the CHB and IHBCS groups compared to the control group (P&lt;0.001). Total aminooxidant and ceruloplasmin levels were found to be lowest in the CHB group and highest in the control group (P&lt;0.001). Sulfhyrdyl was higher in the control group compared to the other groups (P&lt;0.001). In the CHB group, there was no correlation between the HBV DNA and OSI (P&gt;0.05). These finding suggested that oxidative stress is associated with hepatitis B activity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Antioxidants - metabolism</subject><subject>Carrier State</subject><subject>Catalase - blood</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hepatitis B - metabolism</subject><subject>Hepatitis B - pathology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - metabolism</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Oxidative Stress</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Young Adult</subject><subject>병리학</subject><issn>2234-3806</issn><issn>2234-3814</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVUcFOGzEQtapWBQEfwKXyrb1kscfeXftSKdACkaIiIeCEZDleu3HZ7AZ7k5a_Z0IgKr48z8x7zyM_Qo45K4SQ4sS2iwIYh0JAAQXn4gPZBxByJBSXH3d3Vu2Ro5z_MDwV0jX7TPZwprSq631yf-1bO8S-y_O4pH2g_b_YYGPtaR6Sz5nGjs79EltDzPQUy-DdRkAtwjoOT_RvHOb08vSO_vg1prZraIiz1OeYD8mnYNvsj17xgNye_7w5uxxNry4mZ-PpyEnBh1Epa1VpC64p60pzIZXGXUFz52aWexeUlM7VjQIFWjecac4ayxiEIEXdeHFAvm19uxTMg4umt_EFf_fmIZnx9c3EcAkSFFK_b6nL1WzhG-e7IdnWLFNc2PT0Inw_6eIcbdZGgNJ1XaLB11eD1D-ufB7MImbn29Z2vl9lo6EqmSwlIJNvmQ4_Iycfdq9wZjYRGozQbCJEcwMGI0TNl__X2yneAhPPa8yXqA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Duygu, Fazilet</creator><creator>Karsen, Hasan</creator><creator>Aksoy, Nurten</creator><creator>Taskin, Abdullah</creator><general>The Korean Society for Laboratory Medicine</general><general>대한진단검사의학회</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>20120301</creationdate><title>Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis</title><author>Duygu, Fazilet ; Karsen, Hasan ; Aksoy, Nurten ; Taskin, Abdullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-547869a2cd576913489006291ccba1ecf844cc7d828299d10910da002ff437de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Antioxidants - metabolism</topic><topic>Carrier State</topic><topic>Catalase - blood</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hepatitis B - metabolism</topic><topic>Hepatitis B - pathology</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B, Chronic - metabolism</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Oxidative Stress</topic><topic>Sulfhydryl Compounds - blood</topic><topic>Young Adult</topic><topic>병리학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duygu, Fazilet</creatorcontrib><creatorcontrib>Karsen, Hasan</creatorcontrib><creatorcontrib>Aksoy, Nurten</creatorcontrib><creatorcontrib>Taskin, Abdullah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Annals of laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duygu, Fazilet</au><au>Karsen, Hasan</au><au>Aksoy, Nurten</au><au>Taskin, Abdullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis</atitle><jtitle>Annals of laboratory medicine</jtitle><addtitle>Ann Lab Med</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>32</volume><issue>2</issue><spage>113</spage><epage>118</epage><pages>113-118</pages><issn>2234-3806</issn><eissn>2234-3814</eissn><abstract>The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. 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identifier ISSN: 2234-3806
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subjects Adolescent
Adult
Aged
Alanine Transaminase - blood
Antioxidants - metabolism
Carrier State
Catalase - blood
DNA, Viral - analysis
Female
Fibrosis
Hepatitis B - metabolism
Hepatitis B - pathology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - metabolism
Hepatitis B, Chronic - pathology
Humans
Lipid Peroxidation
Male
Middle Aged
Original
Oxidative Stress
Sulfhydryl Compounds - blood
Young Adult
병리학
title Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis
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