Betulinic and Oleanolic Acids Isolated from Forsythia suspensa VAHL Inhibit Urease Activity of Helicobacter pylori

Sixteen medicinal herbs were selected from a database on traditional herbal materials as well as literature on Korean plant resources. Then ethanol (70%, v/v) extracts of these herbs were tested for inhibition of the urease activity of Helicobacter pylori. The urease activity of H. pylori was strong...

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Published in:Biotechnology and bioprocess engineering 2009, 14(2), , pp.140-145
Main Authors: Shin, S.J. (Kyung Hee University, Yongin, Republic of Korea), Park, C.E. (Kyung Hee University, Yongin, Republic of Korea), Baek, N.I. (Kyung Hee University, Yongin, Republic of Korea), Chung, I.S. (Kyung Hee University, Yongin, Republic of Korea), Park, C.H. (Kyung Hee University, Yongin, Republic of Korea), E-mail: chpark@khu.ac.kr
Format: Article
Language:English
Subjects:
Acids
Antibiotics
Biotechnology
Chromatography
Ethanol
Experiments
EXTRACCION
EXTRACTION
Forsythia suspensa
Forsythia suspensa VAHL
HELICOBACTER PYLORI
Herbal medicine
Herbs
Human immunodeficiency virus
Nickel
NMR analysis
Phenols
Plant resources
Silica
Solvent extraction
Solvents
Studies
urease activity
생물공학
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Summary:Sixteen medicinal herbs were selected from a database on traditional herbal materials as well as literature on Korean plant resources. Then ethanol (70%, v/v) extracts of these herbs were tested for inhibition of the urease activity of Helicobacter pylori. The urease activity of H. pylori was strongly (82%) inhibited by extract of Forsythia suspensa VAHL. Active compounds in extract of Forsythia suspensa VAHL were first separated by batch mode solvent extraction, followed by purification by silica gel and octadecyl silica gel column chromatography using solvents of different polarity. According to NMR analysis of the last chromatographic fraction, we identified the presence of betulinic acid and oleanolic acid, which are known to have anti-inflammatory, anti-cancer, and anti-HIV viral activities.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-008-0272-4