Undaria pinnatifida fucoidan extract protects against CCl₄-induced oxidative stress

This study was performed to elucidate the effects of Undaria pinnatifida fucoidan extract (UPFE) in preventing CCl₄-induced oxidative stress. UPFE (100 mg/kg) was intraperitoneally administered to rats for 14 days. On day 15, CCl₄ dissolved in olive oil (50% CCl₄) was injected 12 h before they were...

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Published in:Biotechnology and bioprocess engineering 2008, 13(2), , pp.168-173
Main Authors: Kang, K.S. (Silla University, Busan, Republic of Korea), Kim, I.D. (Silla University, Busan, Republic of Korea), Kwon, R.H. (Silla University, Busan, Republic of Korea), Ha, B.J. (Silla University, Busan, Republic of Korea), E-mail: bjha@silla.ac.kr
Format: Article
Language:English
Subjects:
antioxidative enzyme
Biotechnology
Chemistry
Chemistry and Materials Science
Dehydrogenases
ESTRES
fucoidan
Industrial and Production Engineering
Liver
Olive oil
OXIDACION
OXIDATION
Oxidative stress
OXYDATION
Phosphatase
Proteins
STRESS
UNDARIA PINNATIFIDA
생물공학
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Summary:This study was performed to elucidate the effects of Undaria pinnatifida fucoidan extract (UPFE) in preventing CCl₄-induced oxidative stress. UPFE (100 mg/kg) was intraperitoneally administered to rats for 14 days. On day 15, CCl₄ dissolved in olive oil (50% CCl₄) was injected 12 h before they were anesthetized and dissected. To measure UPFE-mediated antioxidation, we examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in serum, as well as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver homogenates. CCl₄ treatment markedly increased the levels of GOT, GPT, ALP, LDH, and MDA and significantly decreased levels of SOD, CAT, and GPx. UPFE pretreatment decreased levels of GOT, GPT, ALP, LDH, and MDA, by 62.8, 68.5, 41.9, 72.7, and 122%, respectively and increased those of SOD, CAT, and GPx by 111.1, 15.9, and 52.6%, respectively. These results showed that UPFE has antioxidant effects against CCl₄-induced oxidative stress.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-007-0101-1