Effects of Acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis in Mice

Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed....

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Bibliographic Details
Published in:Journal of acupuncture and meridian studies 2017, 10(4), 48, pp.252-260
Main Authors: Chen, Cuicui, Liu, Xiaozhu, Li, Yinfeng, Liang, Huankun, Li, Kangyan, Li, Jiali, Cheng, Chengwu, Liu, Xianpan, Zhong, Shuhai, Li, Laiqing, Wang, Yan
Format: Article
Language:English
Subjects:
acupuncture
Acupuncture Therapy
allergic contact dermatitis
Animals
Cytokines - analysis
Cytokines - metabolism
Dermatitis, Allergic Contact - immunology
Dermatitis, Allergic Contact - pathology
Dermatitis, Allergic Contact - physiopathology
Dermatitis, Allergic Contact - therapy
Dinitrochlorobenzene - adverse effects
Disease Models, Animal
DNCB
Epidermal Growth Factor - analysis
Epidermal Growth Factor - metabolism
Female
Immunoglobulin E - analysis
Mice
Mice, Inbred BALB C
Occludin - analysis
Occludin - metabolism
Skin - chemistry
Skin - drug effects
Skin - pathology
한의학
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Summary:Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1β, TNF-α) mRNA compared with DNCB treatment. Acupuncture treatment also inhibited nuclear factor-κB p65, phosphorylation of IκBα, and phosphorylation of occludin proteins expression. Furthermore, it could improve the expression of epidermal growth factor in both mRNA and protein levels. These results suggest that acupuncture, as an alternative therapy treatment for its no significant side effects, was effective in alleviating ACD by reducing proinflammatory cytokines and changing proteins' expression.
ISSN:2005-2901
2093-8152
DOI:10.1016/j.jams.2017.06.004