Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma

Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distingui...

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Bibliographic Details
Published in:Clinical and experimental pediatrics 2017, 60(9), , pp.290-295
Main Authors: Park, Sang Hoo, Im, Min Ji, Eom, Sang-Yong, Hahn, Youn-Soo
Format: Article
Language:English
Subjects:
Accuracy
Asthma
Child
Maximal expiratory flow-volume curve
Nitric oxide
Original
Pulmonary function testing
Spirometry
소아과학
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Summary:Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals. FeNO and angle β, which characterizes the general configuration of the MEFV curve, were determined in 119 steroid-naïve individuals with atopic asthma aged 8 to 16 years, and in 92 age-matched healthy controls. Receiver operating characteristic (ROC) curve analyses were performed to determine the cutoff points of FeNO and angle β that provided the best combination of sensitivity and specificity for asthma detection. Asthmatic patients had a significantly smaller angle β and higher FeNO compared with healthy controls (both,
ISSN:1738-1061
2092-7258
2713-4148
DOI:10.3345/kjp.2017.60.9.290