Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition

Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and...

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Bibliographic Details
Published in:Biomolecules & therapeutics 2015, 23(1), , pp.12-18
Main Authors: Bae, Ok-Nam, Noh, Minsoo, Chun, Young-Jin, Jeong, Tae Cheon
Format: Article
Language:English
Subjects:
Review
약학
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Summary:Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
ISSN:1976-9148
2005-4483
1976-9148
2005-4483
DOI:10.4062/biomolther.2014.102