Fermented Pueraria Lobata extract ameliorates dextran sulfate sodium-induced colitis by reducing pro-inflammatory cytokines and recovering intestinal barrier function

Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order to eliminate the limitations, herbal medicines have recently been developed for tr...

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Published in:Laboratory animal research 2016, 32(3), , pp.151-159
Main Authors: Choi, Seungho, Woo, Jong-Kyu, Jang, Yeong-Su, Kang, Ju-Hee, Jang, Jung-Eun, Yi, Tae-Hoo, Park, Sang-Yong, Kim, Sun-Yeou, Yoon, Yeo-Sung, Oh, Seung Hyun
Format: Article
Language:English
Subjects:
herbal medicines
IBD
inflammation
intestinal barrier
Original
Pueraria Lobata
수의학
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Summary:Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order to eliminate the limitations, herbal medicines have recently been developed for treatment of IBD. ( ) is one of the traditional herbal medicines that have anti-inflammatory effects. Bioavailability of , which is rich in isoflavones, is lower than that of their fermented forms. In this study, we generated fermented extracts (fPue) and investigated the role of fPue in inflammation and intestinal barrier function and . As the mice or intestinal epithelial cells were treated with DSS/fPue, mRNA expression of pro-inflammatory cytokines was reduced and the architecture and expression of tight junction proteins were recovered, compared to the DSS-treated group. In summary, fPue treatment resulted in amelioration of DSS-induced inflammation in the colon, and the disrupted intestinal barrier was recovered as the expression and architecture of tight junction proteins were retrieved. These results suggest that use of fPue could be a new therapeutic strategy for treatment of IBD.
ISSN:1738-6055
2233-7660
DOI:10.5625/lar.2016.32.3.151