Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice

The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group sh...

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Published in:Laboratory animal research 2012, 28(2), , pp.123-129
Main Authors: Nam, Y.Y., Hallym University, Chuncheon, Republic of Korea, Jung, H.R., Hallym University, Chuncheon, Republic of Korea, Sankarapandian Karuppasamy, Hallym University, Chuncheon, Republic of Korea, Lee, J.Y., Biotopia Co., Ltd., Chuncheon, Republic of Korea, Kang, K.D., Biotopia Co., Ltd., Chuncheon, Republic of Korea, Hwang, K.Y., Biotopia Co., Ltd., Chuncheon, Republic of Korea, Seong, S.I., Biotopia Co., Ltd., Chuncheon, Republic of Korea, Suh, J.G., Hallym University, Chuncheon, Republic of Korea
Format: Article
Language:English
Subjects:
1-deoxynojirimycin
anti-obesity
BACILLUS SUBTILIS
Bacillus subtilis MORI
Fermented soybean extract
lipid-lowering effect
Original
수의학
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Summary:The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P less than 0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P less than 0.05, P less than 0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P less than 0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
ISSN:1738-6055
2233-7660
DOI:10.5625/lar.2012.28.2.123