Multi-electrochemical signal generation using metalloprotein based on selective surface modification

In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-li...

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Bibliographic Details
Published in:Biochip journal 2017, 11(4), , pp.322-328
Main Authors: Chung, Yong-Ho, Yoo, Si-Youl, Yoon, Jinho, Min, Junhong, Choi, Jeong-Woo
Format: Article
Language:English
Subjects:
Bioelectricity
Biomedical Engineering and Bioengineering
Biomedical materials
Biotechnology
Chemistry
Chemistry and Materials Science
Electrodes
Immobilization
Information storage
Logic circuits
Myoglobins
Original Article
Reproducibility
Selective surfaces
Signal generation
생물공학
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Summary:In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-linking materials. Based on controlled signals of myoglobin, multisignal having dual peak is achieved by the signal combination of six electrodes, which have different electrochemical signals by the modification of each electrode with different kinds of chemical linkers individually. For the device formation, selective immobilization process was performed by using reductive cleavage of pre-immobilized thiol group. As a result, the proposed concept shows simple and effective formation of a multi-signal in a single electrochemical signal as compared with other methods based on heterolayer and hybrid materials, and it can be directly applied to materialize practical bioelectronic devices such as a bio-logic gate or bio-computing system
ISSN:1976-0280
2092-7843
DOI:10.1007/s13206-017-1409-3