Altered Biodistribution of 99mTc-DPD on Bone Scan After Intravenous Iron Supplement

We report a case with altered biodistribution of 99m Tc-dicarboxypropane diphosphonate ( 99m Tc-DPD) on whole body bone scan after intravenous iron supplement therapy. A 47-year-old male patient who had recently been detected with a hepatic mass suggestive of hepatocellular carcinoma underwent bone...

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Bibliographic Details
Published in:Nuclear medicine and molecular imaging 2017, 51(4), , pp.347-349
Main Authors: Shin, Eonwoo, Oh, Minyoung, Sung, Changhwan, Kim, Ki-Hun, Ryu, Jin-Sook
Format: Article
Language:English
Subjects:
Anemia
Cardiology
Case Report
Ferric hydroxide
Heart
Imaging
Iron
Liver
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Radiology
Spleen
Technetium isotopes
방사선과학
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Summary:We report a case with altered biodistribution of 99m Tc-dicarboxypropane diphosphonate ( 99m Tc-DPD) on whole body bone scan after intravenous iron supplement therapy. A 47-year-old male patient who had recently been detected with a hepatic mass suggestive of hepatocellular carcinoma underwent bone scan as staging work-up before surgery. Bone scan images at 3 h after injection of 99m Tc-DPD demonstrated unusually increased blood pool activities in the heart, liver, and spleen with usual skeletal uptakes. The patient had been treated for severe anemia from hemorrhoid with two intravenous administration of ferric hydroxide carboxymaltose complex at approximately 22 h and 2 h prior to the 99m Tc-DPD injection, which we consider as the most probable cause of altered biodistribution of 99m Tc-DPD.
ISSN:1869-3474
1869-3482
DOI:10.1007/s13139-017-0486-5