The effect of an Angiotensin receptor blocker on arterial stiffness in type 2 diabetes mellitus patients with hypertension

Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with t...

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Bibliographic Details
Published in:Diabetes & metabolism journal 2011, 35(3), 125, pp.236-242
Main Authors: Kim, Ji Hyun, Oh, Su Jin, Lee, Jung Min, Hong, Eun Gyoung, Yu, Jae Myung, Han, Kyung Ah, Min, Kyung Wan, Son, Hyun Shik, Chang, Sang Ah
Format: Article
Language:English
Subjects:
Angiotensin receptor blocker
Arterial stiffness
Diabetes mellitus
Hypertension
Original
내과학
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Summary:Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with type 2 diabetes and hypertension. We used pulse wave analysis to measure central aortic waveform in a total of 98 subjects. In 47 of these patients, pulse wave velocity measurements were obtained before and after 12 weeks of treatment with valsartan. In the central aortic waveform analysis, the aortic pulse pressure and augmentation index were significantly decreased after valsartan treatment, as was the aortic pulse wave velocity. Factors contributing to the improvement in pulse wave velocity were the fasting blood glucose and haemoglobin A1c levels. Short-term treatment with valsartan improves arterial stiffness in patients with type 2 diabetes and hypertension, and the glucose status at baseline was associated with this effect.
ISSN:2233-6079
2233-6087
DOI:10.4093/dmj.2011.35.3.236