Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients

• Published in: Diabetes & metabolism journal 2011, 35(5), 127, pp.536-542
• Main Authors: Suh, Sunghwan, Park, Hyung-Doo, Kim, Se Won, Bae, Ji Cheol, Tan, Alice Hyun-Kyung, Chung, Hye Soo, Hur, Kyu Yeon, Kim, Jae Hyeon, Kim, Kwang-Won, Lee, Moon-Kyu
• Format: Article
• Language: English
• Subjects: Coronary heart diseases; Diabetes mellitus; LDL particle size; Original; Small dense low density lipoprotein; 내과학
• ISSN: 2233-6079; 2233-6087
• DOI: 10.4093/dmj.2011.35.5.536

Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease. The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications. Diabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P