Secondary Primary Prostate Cancer after Colorectal Cancer: A Nationwide Population-based Cohort Study in Korea

• Published in: Journal of cancer prevention 2017, 22(4), , pp.241-247
• Main Authors: Kim, Hyun Soo, Choi, Yoon Jin, Shin, Dong Woo, Han, Kyung-Do, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Kim, Nayoung, Lee, Dong Ho
• Format: Article
• Language: English
• Subjects: Original; 예방의학
• ISSN: 2288-3649; 2288-3657
• DOI: 10.15430/JCP.2017.22.4.241

Colorectal cancer (CRC) and prostate cancer frequently occur in developed countries. There are several reports on the association between CRC and prostate cancer; however, the conclusions are inconsistent to investigate the association of the development of secondary primary prostate cancer among patients with prior primary CRC using a nationwide population-based dataset. Patients registered in the Republic of Korea National Health Insurance System database who were diagnosed with CRC between 2007 and 2012 were followed-up until the end of 2015, and we investigated the new diagnosis secondary primary prostate cancer. We compared the incidence of prostate cancer in age-matched controls using the Cox proportional hazards models. We analyzed a total of 85,455 first primary CRC survivors. During the follow-up period of 494,222 person-years, 2,005 patients (2.30%) developed secondary primary prostate cancer (incidence rate 4.06/1,000 person-years). The median duration of follow-up was 5.78 years. Compared with the general population, CRC patients had a significantly increased risk of secondary primary prostate cancer (HR = 2.30, 95% CI = 2.18-2.43; < 0.001). Multivariate analysis (including age, sex, body mass index, hypertension, diabetes mellitus, dyslipidemia, and income) showed that age < 55 years (HR = 20.74, 95% CI = 11.81-36.41; < 0.001) is a significant independent predictor of secondary primary prostate cancer development. Men diagnosed with colorectal cancer are at an increased risk of secondary primary prostate cancer, particularly those aged < 55 years. The data suggests that colorectal cancer patients aged < 55 years require regular screening for prostate cancer.