뇌낭미충증과 감별이 어려웠던 폐암의 속립성 뇌전이 1예

Miliary brain metastasis from the lung is uncommon and has a poor therapeutic response. We report a case pulmonary adenocarcinoma combined with multiple brain cystic lesions that were initially misdiagnosed neurocysticercosis. A 53-year-old male who never smoked was admitted to our hospital with com...

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Bibliographic Details
Published in:Tuberculosis and respiratory diseases 2012, 72(2), 325, pp.182-186
Main Authors: 이호준, Ho Jun Lee, 오인재, In Jae Oh, 박상우, Sang Woo Park, 반희정, Hee Jung Ban, 김영철, Young Chul Kim, 김수옥, Soo Ok Kim
Format: Article
Language:Korean
Subjects:
Brain
Gefitinib
Neoplasm Metastasis
Neurocysticercosis
내과학
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Summary:Miliary brain metastasis from the lung is uncommon and has a poor therapeutic response. We report a case pulmonary adenocarcinoma combined with multiple brain cystic lesions that were initially misdiagnosed neurocysticercosis. A 53-year-old male who never smoked was admitted to our hospital with complaints of agitation and cognitive impairment. Brain magnetic resonance imaging showed innumerable, small nodular lesions with central, low signal intensity in whole brain parenchyma. His symptoms were not improved by the empirical praziquantel medication for disseminated neurocysticercosis. After a transbronchial biopsy from the right middle lobe, we could diagnose the primary lung adenocarcinoma with a single nucleotide polymorphism in the epidermal growth factor receptor exon 20 at codon 787 (Q787Q). His neurologic symptoms and imaging findings have been gradually improving with a first-line Gefitinib treatment for five months. We recommend a more active diagnostic approach including biopsy in case of atypical imaging findings.
ISSN:1738-3536
2005-6184