Modeling of a nanofilter and its application to the separation of DNA

We consider a nanofilter device that has been used experimentally for separation of DNA (Deoxyribonucleic acid) with different lengths less than thousands of base pairs. We introduce a master equation for describing the dynamics of DNA in a nanofilter under an external electric field, and obtain the...

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Bibliographic Details
Published in:Journal of the Korean Physical Society 2018, 72(2), , pp.320-325
Main Author: Park, Pyeong Jun
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Mathematical and Computational Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Separation
Theoretical
물리학
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Summary:We consider a nanofilter device that has been used experimentally for separation of DNA (Deoxyribonucleic acid) with different lengths less than thousands of base pairs. We introduce a master equation for describing the dynamics of DNA in a nanofilter under an external electric field, and obtain the probability distribution of DNA for a given nanofilter geometry. Our results are consistent with experimental results and provide an estimate of the minimum device size required to obtain the target separation resolution in the separation of DNA.
ISSN:0374-4884
1976-8524
DOI:10.3938/jkps.72.320