Adiponectin gene SNP 276G→T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients

• Published in: Nutrition research and practice 2007, 1(4), , pp.363-370
• Main Authors: Yu, S.Y. (Ewha Womans University, Seoul, Republic of Korea), Ryu, H.K. (Ewha Womans University, Seoul, Republic of Korea), Park, H.J. (CJ Corp. Foods RnD, Seoul, Republic of Korea), Choi, Y.J. (21C Diabetics and Vascular Research Center, Seoul, Republic of Korea), Huh, K.B. (21C Diabetics and Vascular Research Center, Seoul, Republic of Korea), Kim, W.Y. (Ewha Womans University, Seoul, Republic of Korea), E-mail: [e-mail]
• Format: Article
• Language: English
• Subjects: adiponectin; cardiovascular disease risk factors; CARDIOVASCULAR DISEASES; ENFERMEDADES CARDIOVASCULARES; insulin resistance; MALADIE CARDIOVASCULAIRE; Original Research; type 2 diabetes; 생활과학
• ISSN: 1976-1457; 2005-6168
• DOI: 10.4162/nrp.2007.1.4.363

Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G→T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G→T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype.