The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa ( ) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Eighty-seven children with ADHD (mean age, 9.23±1.99 years...

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Published in:Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 2017, 15(3), , pp.222-228
Main Authors: Kim, Eunjoo, Song, Dong-Ho, Kim, Nam-Wook, Sohn, In-Jung, Cheon, Keun-Ah
Format: Article
Language:English
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정신과학
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Summary:This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa ( ) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T＞G) of was genotyped to examine the association with CPT performance. We found significantly more omission errors on the CPT among children with the TT genotype of (t=2.56, =0.012) after correcting for multiple testing. Our results suggest the possible involvement of the 1065 T＞G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
ISSN:1738-1088
2093-4327
DOI:10.9758/cpn.2017.15.3.222