Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extr...

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Bibliographic Details
Published in:Journal of veterinary science (Suwŏn-si, Korea) 2016, 17(1), , pp.97-102
Main Authors: Chung, Hyo-jin, Chung, Wook-hun, Lee, Jae-Hoon, Chung, Dai-Jung, Yang, Wo-Jong, Lee, A-Jin, Choi, Chi-Bong, Chang, Hwa-Seok, Kim, Dae-Hyun, Suh, Hyun Jung, Lee, Dong-Hun, Hwang, Soo-Han, Do, Sun Hee, Kim, Hwi-Yool
Format: Article
Language:English
Subjects:
Animals
Brain-Derived Neurotrophic Factor - genetics
Cord Blood Stem Cell Transplantation
Enzyme-Linked Immunosorbent Assay
Gene Expression Profiling
Gene Expression Regulation
Humans
Locomotion
Nerve Growth Factor - genetics
Original
Rats
Spinal Cord Injuries - therapy
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Summary:We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2016.17.1.97