Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

Vitamin D3 up-regulated protein 1 is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout mice exhibited accelerated liver regeneration because such animals could effectively control the ex...

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Bibliographic Details
Published in:Journal of veterinary science (Suwŏn-si, Korea) 2013, 14(3), , pp.257-262
Main Authors: Kwon, H.J., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Hong, S.K., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Yoon, W.K., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Nam, K.H., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Choi, I.P., Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea, Kim, D.Y., Seoul National University, Seoul, Republic of Korea, Kim, H.C., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea, Won, Y.S., Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
Format: Article
Language:English
Subjects:
Animals
Blotting, Western
c-jun-N-terminal kinase, NF-kB, partial hepatechtomy
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Proliferation
Gene Expression Regulation
Hepatectomy
Hepatocytes - cytology
Hepatocytes - physiology
JNK Mitogen-Activated Protein Kinases - genetics
JNK Mitogen-Activated Protein Kinases - metabolism
Liver - physiology
Male
Mice, Knockout
NF-kappa B - genetics
NF-kappa B - metabolism
Original
Polymerase Chain Reaction
Regeneration
STAT3 Transcription Factor - genetics
STAT3 Transcription Factor - metabolism
Thioredoxins - genetics
Thioredoxins - metabolism
VITAMIN D
VITAMINA D
VITAMINE D
수의학
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Description
Summary:Vitamin D3 up-regulated protein 1 is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout mice exhibited accelerated liver regeneration because such animals could effectively control the expression of cell cycle regulators that drive the G1-to-S phase progression.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2013.14.3.257