Effect of oxytocin infusion on luteal blood flow and progesterone secretion in dairy cattle

• Published in: Journal of veterinary science (Suwŏn-si, Korea) 2012, 13(1), , pp.67-71
• Main Authors: Brozos, Christos N., Aristotle University of Thessaloniki, Thessaloniki, Greece, Pancarci, Metin S., University of Kafkas, Kars, Turkey, Valencia, Javier, University of Mexico, Mexico City, Mexico, Beindorff, Nikola, University of Veterinary Medicine, Hanover, Germany, Tsousis, Georgios, Aristotle University of Thessaloniki, Thessaloniki, Greece, Kiossis, Evaggelos, Aristotle University of Thessaloniki, Thessaloniki, Greece, Bollwein, Heinrich, University of Veterinary Medicine, Hanover, Germany
• Format: Article
• Language: English
• Subjects: Animals; BLOOD CIRCULATION; Cattle - physiology; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; CORPS JAUNE; CORPUS LUTEUM; Corpus Luteum - blood supply; Corpus Luteum - diagnostic imaging; Corpus Luteum - drug effects; Corpus Luteum - metabolism; CUERPO LUTEO; Dinoprost - analogs & derivatives; Dinoprost - blood; Doppler; Estrous Cycle - drug effects; Estrous Cycle - physiology; Female; Immunoenzyme Techniques - veterinary; OCYTOCINE; Organ Size - physiology; Original; OXITOCINA; OXYTOCIN; Oxytocin - pharmacology; Progesterone - blood; Progesterone - metabolism; Random Allocation; Ultrasonography, Doppler, Color - veterinary; 수의학
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2012.13.1.67

The objective of this study was to investigate the effects of oxytocin infusion on corpus luteum (CL) function during early to mid-diestrus by measuring luteal size (LS) and luteal blood flow (LBF) along with plasma levels of progesterone (P4) and prostaglandin metabolites (13,14-dihydro-15-keto-prostaglandin F∧2α, PGFM). On clay (D) 7 of the estrus cycle (D1 = ovulation), seven cows received 100 IU of oxytocin (OXY) or placebo (PL) following a Latin square design. LS and LBF increased in both groups over time and no differences were observed between the groups. PGFM did not differ either within the groups over time or between the groups at any time point. P4 of the OXY group was higher compared to that of the the PL group 360 min after the infusion (p = 0.01) and tended to be higher at the time points 450 min, 48 h, and 72 h (all p = 0.08). Results from this study support the hypothesis that OXY is not directly involved in the mechanism(s) governing blood now of the CL and has no remarkable effects either on luteal size or P4 and PGFM plasma levels. Further investigation is needed to elucidate the role of OXY in CL blood flow during early and late luteal phases.