Identification of single-nucleotide polymorphisms of the prion protein gene in sika deer (Cervus nippon laiouanus)

Polymorphisms of the prion protein gene (PRNP) have been detected in several cervid species. In order to confirm the genetic variations, this study examined the DNA sequences of the PRNP obtained from 33 captive sika deer (Cervus nippon laiouanus) in Korea. A total of three single-nucleotide polymor...

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Bibliographic Details
Published in:Journal of veterinary science (Suwŏn-si, Korea) 2007, 8(3), , pp.299-301
Main Authors: Jeong, H.J. (Konkuk University, Seoul, Republic of Korea), Lee, J.B. (Konkuk University, Seoul, Republic of Korea), Park, S.Y. (Konkuk University, Seoul, Republic of Korea), Song, C.S. (Konkuk University, Seoul, Republic of Korea), Kim, B.S. (Seoul Grand Park Zoo, Gwacheon, Republic of Korea), Rho, J.R. (Seoul Grand Park Zoo, Gwacheon, Republic of Korea), Yoo, M.H. (Seoul Grand Park Zoo, Gwacheon, Republic of Korea), Jeong, B.H. (Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea), Kim, Y.S. (Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea), Choi, I.S. (Konkuk University, Seoul, Republic of Korea), E-mail: ischoi@konkuk.ac.kr
Format: Article
Language:English
Subjects:
Animals
Base Sequence
CERVUS NIPPON
Deer - genetics
DNA - chemistry
DNA - genetics
Genetic Variation
Molecular Sequence Data
Polymerase Chain Reaction - veterinary
Polymorphism, Single Nucleotide
Prions - genetics
PRNP
Sequence Analysis, DNA
Short Communication
single-nucleotide polymorphism
수의학
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Summary:Polymorphisms of the prion protein gene (PRNP) have been detected in several cervid species. In order to confirm the genetic variations, this study examined the DNA sequences of the PRNP obtained from 33 captive sika deer (Cervus nippon laiouanus) in Korea. A total of three single-nucleotide polymorphisms (SNPs) at codons 100, 136 and 226 in the PRNP of the sika deer were identified. The polymorphic site located at codon 100 has not been reported. The SNPs detected at codons 100 and 226 induced amino acid substitutions.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2007.8.3.299