Effects of Xanthium stramarium and Psoralea corylifolia Extracts Combined with UVA1 Irradiation on the Cell Proliferation and TGF-β1 Expression of Keloid Fibroblasts

Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), phototoxic oriental medicinal plants, has been used in traditional medicines in Asian countries. The effects of highly purified XAS or PSC extract combined with ultraviolet A1 (UVA1) irradiation on cell proliferation and transforming growth f...

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Published in:Annals of dermatology 2013, 25(3), , pp.304-309
Main Authors: Park, Sun Yi, Park, Ji-Youn, Kim, Chul-Ho, Kang, Sung Un, Kim, Jong-Hyun, Bark, Ki-Min, Kim, Tae Heung, Shin, Sung Chul, Kang, Hee Young
Format: Article
Language:English
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피부과학
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Summary:Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), phototoxic oriental medicinal plants, has been used in traditional medicines in Asian countries. The effects of highly purified XAS or PSC extract combined with ultraviolet A1 (UVA1) irradiation on cell proliferation and transforming growth factor-beta1 (TGF-β1) expression of the keloid fibroblast were being investigated to define potential therapeutic uses for keloid treatments. The keloid fibroblasts were treated with XAS or PSC alone or in the combination with UVA1 irradiation. The cell viability, apoptosis, and expression of TGF-β1 and collagen I were investigated. XAS and PSC in combination with UVA1 irradiation suppressed cell proliferation and induced apoptosis of keloid fibroblasts. Furthermore, the XAS and PSC in combination with UVA1 irradiation inhibited TGF-β1 expression and collagen synthesis in keloid fibroblasts. These findings may open up the possibility of clinically used XAS or PSC in combination with UVA1 irradiation for keloid treatments.
ISSN:1013-9087
2005-3894
DOI:10.5021/ad.2013.25.3.304