Treatment of keratoacanthoma with 5% imiquimod cream and review of the previous report

Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recentl...

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Bibliographic Details
Published in:Annals of dermatology 2011, 23(3), , pp.357-361
Main Authors: Jeon, Hye Chan, Choi, Mira, Paik, Seung Hwan, Ahn, Chang Ho, Park, Hyun Sun, Cho, Kwang Hyun
Format: Article
Language:English
Subjects:
Case Report
피부과학
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Summary:Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara®) has been reported. We present 4 cases of KA treated with topical imiquimod, applied 3 to 4 times a week. Obvious improvement was observed after 4 to 6 weeks of application and the lesions were almost cleared leaving scars after 9 to 11 weeks. These results show that topical imiquimod can be an effective option for the conservative management of KA as previously reported. We also suggest that lesions treated with imiquimod cream should be considered for biopsy to judge histopathological remission after 5 to 8 weeks of application to shorten the duration of the treatment.
ISSN:1013-9087
2005-3894
DOI:10.5021/ad.2011.23.3.357