A Hydroxyurea-induced Leg Ulcer

Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in associati...

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Bibliographic Details
Published in:Annals of dermatology 2009, 21(1), , pp.39-41
Main Authors: Hwang, Seon-Wook, Hong, Soon-Kwon, Kim, Sang-Hyun, Seo, Jong-Keun, Lee, Deborah, Sung, Ho-Suk
Format: Article
Language:English
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Case Report
피부과학
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Summary:Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration, and xerosis. The leg ulcers were refractory to conventional treatment. She had been taking oral hydroxyurea since being diagnosed with essential thrombocytosis in 2002. Hence, we suspected hydroxyurea-induced leg ulcers and discontinued her hydroxyurea treatment; the ulcers gradually healed thereafter. We present a rare case of hydroxyurea-induced leg ulcers in Korea.
ISSN:1013-9087
2005-3894
DOI:10.5021/ad.2009.21.1.39