Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure

This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melt...

Full description

Saved in:
Bibliographic Details
Published in:Molecular & cellular toxicology 2016, 12(2), , pp.111-116
Main Authors: Lee, Hwayoung, Kim, Hyung-Ki, Won, Hansol, Im, Jiyun, Kwon, Jun-Tack, Kim, Hak-Jae
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Life Sciences
Original Paper
Pharmacology/Toxicology
생물학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63
cites cdi_FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63
container_end_page 116
container_issue 2
container_start_page 111
container_title Molecular & cellular toxicology
container_volume 12
creator Lee, Hwayoung
Kim, Hyung-Ki
Won, Hansol
Im, Jiyun
Kwon, Jun-Tack
Kim, Hak-Jae
description This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melting analysis was used to differentiate the genotypes of the polymorphism. Association of clinical characteristics with genotypes as modifiers was estimated after adjusting for age, smoking status, drinking status, and job duration. Genotype and allele frequencies of the polymorphism were found to be associated with LBP. Blood lead levels were not associated with genotype or allele frequencies. Based on these results, it was concluded that G allele carrier (GG or GG+TG) and G allele of EDN1 polymorphism might be a risk factor of lead-related high blood pressure.
doi_str_mv 10.1007/s13273-016-0014-1
format article
fullrecord <record><control><sourceid>nrf_cross</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_2966598</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_kci_go_kr_ARTI_2966598</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63</originalsourceid><addsrcrecordid>eNp9kE9LwzAYh4MoOKcfwFuuHqL506btcQydg4EgE7yFNHm7ZuuSknTIvr3d5tnTe3meF34PQo-MPjNKi5fEBC8EoUwSSllG2BWacFpxUmayuEYTVoiSyIx_36K7lLaUyiyT1QSZBXgYnMEROj244FPrelzD8APgsfYYvA1DC53zmOHNCOM-dMd9iH3r0n4kLO5AW3L2weLWbVpcdyFY3EdI6RDhHt00ukvw8Hen6OvtdT1_J6uPxXI-WxEjOB-IocDr2pqq1o3IBK3LvDC5phkrbc4sQF5LPc7Jra2MEQANb0rLtBCVgLqRYoqeLn99bNTOOBW0O99NULuoZp_rpeKVlHlVjiy7sCaGlCI0qo9ur-NRMapORdWlqBqLqlNRxUaHX5w0sn4DUW3DIfpx0j_SL4loeyU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure</title><source>Springer Nature</source><creator>Lee, Hwayoung ; Kim, Hyung-Ki ; Won, Hansol ; Im, Jiyun ; Kwon, Jun-Tack ; Kim, Hak-Jae</creator><creatorcontrib>Lee, Hwayoung ; Kim, Hyung-Ki ; Won, Hansol ; Im, Jiyun ; Kwon, Jun-Tack ; Kim, Hak-Jae</creatorcontrib><description>This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melting analysis was used to differentiate the genotypes of the polymorphism. Association of clinical characteristics with genotypes as modifiers was estimated after adjusting for age, smoking status, drinking status, and job duration. Genotype and allele frequencies of the polymorphism were found to be associated with LBP. Blood lead levels were not associated with genotype or allele frequencies. Based on these results, it was concluded that G allele carrier (GG or GG+TG) and G allele of EDN1 polymorphism might be a risk factor of lead-related high blood pressure.</description><identifier>ISSN: 1738-642X</identifier><identifier>EISSN: 2092-8467</identifier><identifier>DOI: 10.1007/s13273-016-0014-1</identifier><language>eng</language><publisher>Incheon: The Korean Society of Toxicogenomics and Toxicoproteomics</publisher><subject>Biomedical and Life Sciences ; Cell Biology ; Life Sciences ; Original Paper ; Pharmacology/Toxicology ; 생물학</subject><ispartof>Molecular &amp; Cellular Toxicology, 2016, 12(2), , pp.111-116</ispartof><rights>The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63</citedby><cites>FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002326737$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hwayoung</creatorcontrib><creatorcontrib>Kim, Hyung-Ki</creatorcontrib><creatorcontrib>Won, Hansol</creatorcontrib><creatorcontrib>Im, Jiyun</creatorcontrib><creatorcontrib>Kwon, Jun-Tack</creatorcontrib><creatorcontrib>Kim, Hak-Jae</creatorcontrib><title>Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure</title><title>Molecular &amp; cellular toxicology</title><addtitle>Mol. Cell. Toxicol</addtitle><description>This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melting analysis was used to differentiate the genotypes of the polymorphism. Association of clinical characteristics with genotypes as modifiers was estimated after adjusting for age, smoking status, drinking status, and job duration. Genotype and allele frequencies of the polymorphism were found to be associated with LBP. Blood lead levels were not associated with genotype or allele frequencies. Based on these results, it was concluded that G allele carrier (GG or GG+TG) and G allele of EDN1 polymorphism might be a risk factor of lead-related high blood pressure.</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Life Sciences</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>생물학</subject><issn>1738-642X</issn><issn>2092-8467</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LwzAYh4MoOKcfwFuuHqL506btcQydg4EgE7yFNHm7ZuuSknTIvr3d5tnTe3meF34PQo-MPjNKi5fEBC8EoUwSSllG2BWacFpxUmayuEYTVoiSyIx_36K7lLaUyiyT1QSZBXgYnMEROj244FPrelzD8APgsfYYvA1DC53zmOHNCOM-dMd9iH3r0n4kLO5AW3L2weLWbVpcdyFY3EdI6RDhHt00ukvw8Hen6OvtdT1_J6uPxXI-WxEjOB-IocDr2pqq1o3IBK3LvDC5phkrbc4sQF5LPc7Jra2MEQANb0rLtBCVgLqRYoqeLn99bNTOOBW0O99NULuoZp_rpeKVlHlVjiy7sCaGlCI0qo9ur-NRMapORdWlqBqLqlNRxUaHX5w0sn4DUW3DIfpx0j_SL4loeyU</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Lee, Hwayoung</creator><creator>Kim, Hyung-Ki</creator><creator>Won, Hansol</creator><creator>Im, Jiyun</creator><creator>Kwon, Jun-Tack</creator><creator>Kim, Hak-Jae</creator><general>The Korean Society of Toxicogenomics and Toxicoproteomics</general><general>대한독성 유전단백체 학회</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ACYCR</scope></search><sort><creationdate>20160601</creationdate><title>Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure</title><author>Lee, Hwayoung ; Kim, Hyung-Ki ; Won, Hansol ; Im, Jiyun ; Kwon, Jun-Tack ; Kim, Hak-Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Life Sciences</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>생물학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hwayoung</creatorcontrib><creatorcontrib>Kim, Hyung-Ki</creatorcontrib><creatorcontrib>Won, Hansol</creatorcontrib><creatorcontrib>Im, Jiyun</creatorcontrib><creatorcontrib>Kwon, Jun-Tack</creatorcontrib><creatorcontrib>Kim, Hak-Jae</creatorcontrib><collection>CrossRef</collection><collection>Korean Citation Index</collection><jtitle>Molecular &amp; cellular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hwayoung</au><au>Kim, Hyung-Ki</au><au>Won, Hansol</au><au>Im, Jiyun</au><au>Kwon, Jun-Tack</au><au>Kim, Hak-Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure</atitle><jtitle>Molecular &amp; cellular toxicology</jtitle><stitle>Mol. Cell. Toxicol</stitle><date>2016-06-01</date><risdate>2016</risdate><volume>12</volume><issue>2</issue><spage>111</spage><epage>116</epage><pages>111-116</pages><issn>1738-642X</issn><eissn>2092-8467</eissn><abstract>This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melting analysis was used to differentiate the genotypes of the polymorphism. Association of clinical characteristics with genotypes as modifiers was estimated after adjusting for age, smoking status, drinking status, and job duration. Genotype and allele frequencies of the polymorphism were found to be associated with LBP. Blood lead levels were not associated with genotype or allele frequencies. Based on these results, it was concluded that G allele carrier (GG or GG+TG) and G allele of EDN1 polymorphism might be a risk factor of lead-related high blood pressure.</abstract><cop>Incheon</cop><pub>The Korean Society of Toxicogenomics and Toxicoproteomics</pub><doi>10.1007/s13273-016-0014-1</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1738-642X
ispartof Molecular & Cellular Toxicology, 2016, 12(2), , pp.111-116
issn 1738-642X
2092-8467
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_2966598
source Springer Nature
subjects Biomedical and Life Sciences
Cell Biology
Life Sciences
Original Paper
Pharmacology/Toxicology
생물학
title Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T06%3A50%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nrf_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20relationship%20between%20an%20endothelin%201%20gene%20polymorphism%20and%20lead-related%20high%20blood%20pressure&rft.jtitle=Molecular%20&%20cellular%20toxicology&rft.au=Lee,%20Hwayoung&rft.date=2016-06-01&rft.volume=12&rft.issue=2&rft.spage=111&rft.epage=116&rft.pages=111-116&rft.issn=1738-642X&rft.eissn=2092-8467&rft_id=info:doi/10.1007/s13273-016-0014-1&rft_dat=%3Cnrf_cross%3Eoai_kci_go_kr_ARTI_2966598%3C/nrf_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c322t-c0e2bbdc9baf3430b857c5a0418d51dee5b6a8465dd9cc3eef2f8d1a3393ebf63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true