Altered miRNA expression in lung tissues of patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by airflow limitation. Epigenetic control affects gene expression in the lung, and microRNAs (miRNAs) are one of the primary types of epigenetic modifiers. In this study, lung tissues were obtained from 15 COPD patients...

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Bibliographic Details
Published in:Molecular & cellular toxicology 2017, 13(2), , pp.207-212
Main Authors: Kim, Woo Jin, Lim, Jae Hyun, Hong, Yoonki, Hong, Seok-Ho, Bang, Chi Young, Lee, Jae Seung, Oh, Yeon-Mok, Kim, Ju Han
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Chronic obstructive pulmonary disease
Epigenetics
Gene expression
Life Sciences
Lung diseases
miRNA
Molecular modelling
Obstructive lung disease
Original Paper
Pharmacology/Toxicology
Respiratory function
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Summary:Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by airflow limitation. Epigenetic control affects gene expression in the lung, and microRNAs (miRNAs) are one of the primary types of epigenetic modifiers. In this study, lung tissues were obtained from 15 COPD patients and 11 subjects with normal lung function. RNA was isolated from the samples, and small RNA sequencing was performed and miRNAs that were differentially expressed between the COPD and control lungs were identified. A total of 12 miRNAs were shown to be differentially expressed (false discovery rate (FDR)
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-017-0022-9