Genomic approach to understand association between single nucleotide polymorphisms and risk of Korean serous ovarian cancer at stage IIIc

Globally, ovarian cancer is responsible for approximately 125,000 deaths each year. Identifying the genetic contributions to ovarian cancer will lead to advances in diagnosis and therapy. Here we analyzed SNPs through genotyping in Korean serous ovarian cancer patients at stage IIIc for the purpose...

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Bibliographic Details
Published in:Molecular & cellular toxicology 2016, 12(1), , pp.21-28
Main Authors: Kim, Hyun Soo, Kim, Yeo Jin, Ahn, Woong Shick, Kwon, Jee Young, Seo, Young Rok
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Life Sciences
Original Paper
Pharmacology/Toxicology
생물학
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Summary:Globally, ovarian cancer is responsible for approximately 125,000 deaths each year. Identifying the genetic contributions to ovarian cancer will lead to advances in diagnosis and therapy. Here we analyzed SNPs through genotyping in Korean serous ovarian cancer patients at stage IIIc for the purpose of applying a pathway analysis-based approach using candidate loci. The results of statistical analysis based on the Korean HapMap showed that a total of 759 SNPs had significant differences in ovarian cancer. Our biological pathway analysis included the comparison of all SNPs with SNPs of serous ovarian cancer patients in The Cancer Genome Atlas (TCGA) to identify the molecular pathway in Korean serous ovarian cancer. The results suggest that genetic alterations associated with these signaling pathways might contribute to the discovery of unique biomarkers for diagnostic predictor of Korean serous ovarian cancer at stage IIIc.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-016-0004-3