Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of enteroviral meningitis

Meningitis is among the most common infections affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the infection and patients are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristic...

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Bibliographic Details
Published in:Clinical and experimental pediatrics 2015, 58(11), , pp.446-450
Main Authors: Jin, Dahee, Heo, Tae Hoon, Byeon, Jung Hye, Kim, Gun-Ha, Kim, Mi Kyung, Eun, So-Hee, Eun, Baik-Lin
Format: Article
Language:English
Subjects:
Adenoviruses
Age
Antibiotics
Cerebrospinal fluid
Demographics
Enterovirus
Etiology
Glucose
Influenza
Laboratories
Meningitis
Organisms
Original
Pathogens
Patients
Polymerase chain reaction
Proteins
Respiratory syncytial virus
Reverse transcriptase polymerase chain reaction
Streptococcus infections
Viruses
Vomiting
소아과학
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Summary:Meningitis is among the most common infections affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the infection and patients are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of enteroviral meningitis in children and evaluate the diagnostic efficacy of reverse transcriptase-polymerase chain reaction (RT-PCR) for early detection of an enterovirus. We analyzed the medical records of children admitted to Korea University Medical Center and diagnosed with meningitis on the basis of cerebrospinal fluid (CSF) analysis and RT-PCR from CSF and other samples from January 2010 to August 2013. A total of 333 patients were enrolled and classified into four groups based on diagnosis: enteroviral meningitis (n=110), bacterial meningitis (n=23), other viral meningitis (n=36), and unknown etiology (n=164). Patients with bacterial meningitis were younger than those in the other groups (P
ISSN:1738-1061
2092-7258
2713-4148
DOI:10.3345/kjp.2015.58.11.446