Cardiomyopathies in children

Cardiomyopathy (CMP) is a heterogeneous disease caused by a functional abnormality of the cardiac muscle. CMP is of 2 major types, dilated and hypertrophic, and is further classified as either primary or secondary. Secondary CMP is caused by extrinsic factors, including infection, ischemia, hyperten...

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Bibliographic Details
Published in:Clinical and experimental pediatrics 2013, 56(2), , pp.52-59
Main Author: Hong, Young Mi
Format: Article
Language:English
Subjects:
Age groups
Cardiomyopathy
Cardiomyopaties
Child
Classification
Congenital diseases
Disease
Families & family life
Family medical history
Genes
Heart failure
Metabolic disorders
Mutation
Myocarditis
Neuromuscular diseases
Pediatrics
Review
소아과학
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Summary:Cardiomyopathy (CMP) is a heterogeneous disease caused by a functional abnormality of the cardiac muscle. CMP is of 2 major types, dilated and hypertrophic, and is further classified as either primary or secondary. Secondary CMP is caused by extrinsic factors, including infection, ischemia, hypertension, and metabolic disorders. Primary CMP is diagnosed when the extrinsic factors of secondary CMP are absent. Furthermore, the World Health Organization, American Heart Association, and European Cardiology Association have different systems for clinically classifying primary CMP. Primary CMP is rare and associated with a family history of the disease, implying that genetic factors might affect its incidence. In addition, the incidence of CMP varies widely according to patient ethnicity. Genetic testing plays an important role in the care of patients with CMP and their families because it confirms diagnosis, determines the appropriate care for the patient, and possibly affects patient prognosis. The diagnosis and genetic identification of CMP in patients' families allow the possibility to identify novel genes that may lead to new treatments. This review focuses on the epidemiology, pathophysiology, diagnosis, and treatment of CMP, with the aim of providing pediatricians with insights that may be helpful in the early identification and management of idiopathic CMP in children.
ISSN:1738-1061
2092-7258
2713-4148
DOI:10.3345/kjp.2013.56.2.52