Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma

• Published in: Clinical and experimental pediatrics 2011, 54(11), , pp.456-462
• Main Authors: Ju, Yanghua, Choi, Seung Jun, Lee, Huisu, Kim, Hyun Sook, Won, Sulmui, Chun, Yoon Hong, Yoon, Jong-Seo, Kim, Hyun Hee, Lee, Joon Sung
• Format: Article
• Language: English
• Subjects: Animal models; Asthma; Chemokines; Infections; Inflammation; Neutrophils; Original; Polymerase chain reaction; Proteins; RANTES; Respiratory syncytial virus; Viruses; 소아과학
• ISSN: 1738-1061; 2092-7258; 2713-4148
• DOI: 10.3345/kjp.2011.54.11.456

Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question. We prepared Dermatophagoides farinae-sensitized mice as an asthma model, and then infected them with RSV and analyzed the changes in airway responsiveness and the cell populations and cytokine levels of bronchoalveolar lavage fluid. RANTES synthesis increased in response to RSV infection in both control mice and in asthma model (D. farinae) mice. However, there was no significant difference in the amount of RANTES produced following RSV infection between control and D. farinae mice. RSV infection affected neither interferon-γsynthesis nor airway responsiveness in either control or D. farinae mice. RSV infection did not induce more RANTES in a murine model of asthma than in control mice.