Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway

Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. In the present study, we showed that endothelial nitric oxide synthase (eNOS) regulates retinal angiogenesis. Mice that lack eNOS showed growth retardation, and retinal vessel developm...

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Bibliographic Details
Published in:The Korean journal of physiology & pharmacology 2016, 20(5), , pp.533-538
Main Authors: Ha, Jung Min, Jin, Seo Yeon, Lee, Hye Sun, Shin, Hwa Kyoung, Lee, Dong Hyung, Song, Sang Heon, Kim, Chi Dae, Bae, Sun Sik
Format: Article
Language:English
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약리학
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Summary:Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. In the present study, we showed that endothelial nitric oxide synthase (eNOS) regulates retinal angiogenesis. Mice that lack eNOS showed growth retardation, and retinal vessel development was significantly delayed. In addition, the number of tip cells and filopodia length were significantly reduced in mice lacking eNOS. Retinal endothelial cell proliferation was significantly blocked in mice lacking eNOS, and EMG-2-induced endothelial cell sprouting was significantly reduced in aortic vessels isolated from eNOS-deficient mice. Finally, pericyte recruitment to endothelial cells and vascular smooth muscle cell coverage to blood vessels were attenuated in mice lacking eNOS. Taken together, we suggest that the endothelial cell function and blood vessel maturation are regulated by eNOS during retinal angiogenesis.
ISSN:1226-4512
2093-3827
DOI:10.4196/kjpp.2016.20.5.533