Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN),...

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Bibliographic Details
Published in:The Korean journal of physiology & pharmacology 2008, 12(2), , pp.79-81
Main Authors: Jung, Jun-Sub, Yan, Ji-Jing, Song, Dong-Keun
Format: Article
Language:English
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약리학
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Summary:The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-α, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.
ISSN:1226-4512
2093-3827
DOI:10.4196/kjpp.2008.12.2.79