Effect of processing method on platycodin D content in Platycodon grandiflorum roots

Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD metho...

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Bibliographic Details
Published in:Archives of pharmacal research 2017, 40(9), , pp.1087-1093
Main Authors: Kwon, Jaeyoung, Lee, Hyaemin, Kim, Nahyun, Lee, Je-Hyun, Woo, Mi Hee, Kim, Jinwoong, Kim, Yeong Shik, Lee, Dongho
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid - methods
Far East
Medicine
Pharmacology/Toxicology
Pharmacy
Plant Roots
Platycodon - chemistry
Research Article
Saponins - chemistry
Saponins - isolation & purification
Temperature
Triterpenes - chemistry
Triterpenes - isolation & purification
약학
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Summary:Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC–ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC–ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40 °C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-017-0946-6